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(http://blogs.plos.org/speakingofmedicine/2014/03/10/book-review-deadly-medicines-organised-crime-big-pharma-corrupted-healthcare-peter-gotzsche/)
‘Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare’ by Peter Gøtzsche
Tom Yates from University College London reviews Peter Gøtzsche’s recent book about the pharmaceutical industry.
I have long been concerned about the conduct of drug companies. I worry about pervasive conflict of interest in the generation, synthesis and dissemination of the evidence that guides my clinical practice. So, when I was asked to review Peter Gøtzsche’s book on these topics, I was excited.
It is hard to imagine someone better qualified to write this book: a biology and chemistry graduate, Peter Gøtzsche began his career as a sales rep for Astra. In 1977, he took responsibility for setting up a medical department at Astra-Syntex and saw from the inside how trials can be abused to build a case for particular products – in his case Naproxen, a non steroidal anti-inflammatory drug (NSAID). In 1978 he started medical school, whilst still working for the company, only leaving Astra-Syntex on qualification six years later.
Gøtzsche’s PhD focussed on bias in randomised controlled trials of NSAIDs for rheumatoid arthritis, generating important results regarding the impact of funding on outcome. He went on to help found the Cochrane Collaboration and to found the Nordic Cochrane Centre. His academic career has focussed on bias, trials and evidence synthesis.
Before I review Deadly Medicines and Organised Crime, I wish to state unequivocally that I agree with Gøtzsche on many fundamental points. I think that industry funded research is inefficient and systematically favours the products of the sponsor. I am appalled by pervasive hidden trials data and publication bias. As receipt of information from industry appears to be harmful, I think industry should play no role in medical education. The current model is clearly broken and some of the solutions Gøtzsche suggests, for example requiring independent trials before licensing medicines, are good ones.
Given the importance of raising these issues, particularly with prescribers, and the obvious expertise Gøtzsche had to draw on, it is a real shame this is not a better book. The sentences are long and often muddled. Chapter three, in particular, is almost unreadable. The superlatives and hyperbole are pervasive, tiresome and, in places, a little offensive:
Gøtzsche tries to cram in too many anecdotes and ideas, many of them not clearly related to the preceding sentences. Chapter 21, the book’s manifesto for change, attempts to take on income inequality, the financial crisis and the organisation of US healthcare, in addition to the regulation of health research.
Given Gøtzsche’s background in evidence synthesis, a surprising feature of the book is the frequency with which strong assertions are backed up with stories, reference to a single trial or, occasionally, simply left unreferenced............................................
I have long been concerned about the conduct of drug companies. I worry about pervasive conflict of interest in the generation, synthesis and dissemination of the evidence that guides my clinical practice. So, when I was asked to review Peter Gøtzsche’s book on these topics, I was excited.
It is hard to imagine someone better qualified to write this book: a biology and chemistry graduate, Peter Gøtzsche began his career as a sales rep for Astra. In 1977, he took responsibility for setting up a medical department at Astra-Syntex and saw from the inside how trials can be abused to build a case for particular products – in his case Naproxen, a non steroidal anti-inflammatory drug (NSAID). In 1978 he started medical school, whilst still working for the company, only leaving Astra-Syntex on qualification six years later.
Gøtzsche’s PhD focussed on bias in randomised controlled trials of NSAIDs for rheumatoid arthritis, generating important results regarding the impact of funding on outcome. He went on to help found the Cochrane Collaboration and to found the Nordic Cochrane Centre. His academic career has focussed on bias, trials and evidence synthesis.
Before I review Deadly Medicines and Organised Crime, I wish to state unequivocally that I agree with Gøtzsche on many fundamental points. I think that industry funded research is inefficient and systematically favours the products of the sponsor. I am appalled by pervasive hidden trials data and publication bias. As receipt of information from industry appears to be harmful, I think industry should play no role in medical education. The current model is clearly broken and some of the solutions Gøtzsche suggests, for example requiring independent trials before licensing medicines, are good ones.
Given the importance of raising these issues, particularly with prescribers, and the obvious expertise Gøtzsche had to draw on, it is a real shame this is not a better book. The sentences are long and often muddled. Chapter three, in particular, is almost unreadable. The superlatives and hyperbole are pervasive, tiresome and, in places, a little offensive:
‘Drug reps are advised to work with key opinion leaders and turn them into ‘product champions’, and also to find younger people who can have their profile raised so that they also become key opinion leaders. A bit like Hitler-Jugend, so they can go out and terrorise common sense among those who are not yet members of the Party.’ (p. 82)‘Whore doctors’, bizarrely, is indexed.
‘…the results generated huge ‘controversy’, with innumerable letters and papers written by seemingly independent whore doctors who were hired guns for the company.’ (p. 100)
Gøtzsche tries to cram in too many anecdotes and ideas, many of them not clearly related to the preceding sentences. Chapter 21, the book’s manifesto for change, attempts to take on income inequality, the financial crisis and the organisation of US healthcare, in addition to the regulation of health research.
Given Gøtzsche’s background in evidence synthesis, a surprising feature of the book is the frequency with which strong assertions are backed up with stories, reference to a single trial or, occasionally, simply left unreferenced............................................
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